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Impact of intrauterine growth restriction on preterm lung disease
Author(s) -
Sasi Arun,
Abraham Vinita,
DaviesTuck Miranda,
Polglase Graeme R.,
Jenkin Graham,
Miller Suzanne L.,
Malhotra Atul
Publication year - 2015
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.13220
Subject(s) - medicine , intrauterine growth restriction , gestation , bronchopulmonary dysplasia , respiratory disease , obstetrics , subgroup analysis , lung disease , pediatrics , gestational age , lung , pregnancy , meta analysis , genetics , biology
Aim Intrauterine growth restriction ( IUGR ) is an important cause for prematurity and adversely influences prematurity‐related morbidities. This study evaluates the impact of IUGR on respiratory outcomes in infants <32 weeks with IUGR and birthweight <10th centile ( SGA ) compared to matched appropriate for gestation ( AGA ) controls. Methods The primary outcomes of this retrospective study are short‐term pulmonary outcomes of chronic lung disease ( CLD ), CLD or death, and need for home oxygen at discharge. Subgroup analysis by gestation‐based stratification (<28 and ≥28 <32 weeks) was decided a priori . Results Total of 153 IUGR and 306 non‐ IUGR infants were enrolled. The rate of CLD (45% vs. 17%, p = 0.0001), death (16% vs. 4.6%, p = 0.0001), CLD or death (46% vs. 21.5%, p = 0.0001), home oxygen rates (13.7% vs. 6.5%, p = 0.01) and duration of respiratory support was significantly higher in the IUGR group. IUGR emerged as the strongest predictor of CLD (adjusted OR , 95% CI : (8.4 [2, 35]) and CLD or death (12.7 [3, 54]) across all gestation. Conclusion IUGR is a major risk factor for adverse short‐term pulmonary outcomes as reflected by higher rates of CLD , CLD or death, and oxygen dependency at discharge in preterm infants.