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Current evidence on whether perinatal risk factors influence coeliac disease is circumstantial
Author(s) -
Mårild Karl,
Ludvigsson Jonas F.,
Størdal Ketil
Publication year - 2016
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.13150
Subject(s) - circumstantial evidence , coeliac disease , medicine , disease , pathology , political science , law
Coeliac disease is triggered by an interplay of environmental and genetic factors and is one of the most prevalent autoimmune diseases in children, occurring in about 1% of Europeans. Over the last few decades, there has been a growing interest in the role of the perinatal environment in coeliac disease and this review discusses the growing body of literature on coeliac disease and perinatal risk factors. Conclusion There is still only circumstantial evidence that the perinatal environment influences coeliac disease development. Large‐scale cohort studies and emerging scientific concepts, such as epigenetics, may help us establish the role of these environmental factors.