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Gluten and casein supplementation does not increase symptoms in children with autism spectrum disorder
Author(s) -
Pusponegoro Hardiono D.,
Ismael Sofyan,
Firmansyah Agus,
Sastroasmoro Sudigdo,
Vandenplas Yvan
Publication year - 2015
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.13108
Subject(s) - medicine , autism spectrum disorder , autism , gluten , casein , pediatrics , psychiatry , food science , pathology , chemistry
Aim A gluten‐ and casein‐free diet is often given to children with autism spectrum disorder ( ASD ). We aimed to determine the effect of gluten and casein supplementation on maladaptive behaviour, gastrointestinal symptom severity and intestinal fatty acids binding protein (I‐ FABP ) excretion in children with ASD . Methods A randomised, controlled, double‐blind trial was performed on 74 children with ASD with severe maladaptive behaviour and increased urinary I‐ FABP . Subjects were randomised to receive gluten–casein or a placebo for seven days. We evaluated maladaptive behaviour before and after supplementation, using I‐ FABP excretion, the approach withdrawal problem composite subtest of the Pervasive Developmental Disorder Behavior Inventory and the Gastrointestinal Symptom Severity Index. Results The mean approach withdrawal problem composite score was significantly higher before supplementation than after, both in the placebo and in the gluten–casein group. However, the mean difference was not significant and may have been caused by additional therapy. There was no significant difference in gastrointestinal symptoms and urinary I‐ FABP excretion. Conclusion Administrating gluten–casein to children with ASD for one week did not increase maladaptive behaviour, gastrointestinal symptom severity or urinary I‐ FABP excretion. The effect of prolonged administration or other mechanisms of enterocyte damage in ASD should be explored.