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Using adrenaline during neonatal resuscitation may have an impact on serum cardiac troponin‐T levels
Author(s) -
Helmer Caroline,
Skranes Janne H.,
Liestøl Knut,
Fugelseth Drude
Publication year - 2015
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.13055
Subject(s) - medicine , troponin complex , cardiopulmonary resuscitation , apgar score , anesthesia , resuscitation , ventilation (architecture) , epinephrine , univariate analysis , encephalopathy , troponin , cardiology , myocardial infarction , birth weight , multivariate analysis , pregnancy , mechanical engineering , biology , engineering , genetics
Aim It has been suggested that serum cardiac troponin‐T ( cTnT ) can predict the severity of neonatal hypoxic–ischaemic encephalopathy. We evaluated whether cTnT was better correlated with adrenaline during cardiopulmonary resuscitation ( CPR ) than with the severity of the insult itself, based on the Apgar scores. Methods Serum cTnT was analysed in 47 asphyxiated newborn infants treated with hypothermia. Blood samples and resuscitation data were collected from medical records, and multiple linear regressions were used to evaluate the effect of the treatment and the Apgar scores on cTnT levels. Results The infants were divided into three groups: the no CPR group (n = 29) just received stimulation and ventilation, the CPR minus adrenaline group (n = 9) received cardiac compression and ventilation and the CPR plus adrenaline group (n = 9) received complete CPR , including adrenaline. In the univariate analysis, the five and ten‐minute Apgar scores were significantly lower in the CPR plus adrenaline group and the cTnT was significantly higher. Multiple regression analysis showed significantly higher cTnT values in the CPR plus adrenaline group, but no significant relationship between cTnT and the Apgar scores. Conclusion Although cTnT correlated with the severity of the insult in neonatal hypoxic–ischaemic encephalopathy, the levels may have been affected by adrenaline administered during CPR .