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Treating retinoblastoma in the first year of life in a national tertiary paediatric hospital in Mexico
Author(s) -
AsencioLópez Laura,
TorresOjeda Alan A.,
IsaacOtero Gabriela,
LealLeal Carlos A.
Publication year - 2015
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.13033
Subject(s) - medicine , retinoblastoma , pediatrics , family history , malignancy , medical record , retrospective cohort study , disease , survival rate , age of onset , underweight , young adult , stage (stratigraphy) , surgery , body mass index , biochemistry , chemistry , gene , overweight , paleontology , biology
Aim Retinoblastoma is the most common primary ocular malignancy in childhood, but little has been documented on the clinical and biological differences in children diagnosed before one year of age. We observed patients in this age group and followed them for up to 19 years. Methods This retrospective, descriptive, observational study reviewed the medical records of Mexican patients, who were diagnosed with retinoblastoma before one year of age at a national paediatric hospital from 1995 to 2014. The variables analysed were age at diagnosis, weight, presenting signs, the time from first symptoms to diagnosis, family history, laterality, ocular rescue and survival rate. Results The 108 patients had a mean age of 7.65 months and 15.7% had a family history of retinoblastoma. The majority (55.5%) had bilateral retinoblastoma, the most common presenting sign was leukocoria (86.1%), and the most common stage of diagnosis was Group V (84.1%). More than half were underweight for their age. The overall survival rate was 92% and the disease‐free survival rate was 84%. Conclusion Retinoblastoma is a malignancy that can be present at birth, especially if it is a bilateral hereditary form of the disease. Leukocoria was the main presenting sign. Early diagnosis dramatically improved the prognosis for ocular rescue.