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Anti‐ S accharomyces cerevisiae antibody titres correlate well with disease activity in children with C rohn's disease
Author(s) -
ElMatary Wael,
Dupuis Karine,
Sokoro AbdulRazaq
Publication year - 2015
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.13026
Subject(s) - medicine , antibody , crohn's disease , immunoglobulin a , immunology , disease , inflammatory bowel disease , albumin , c reactive protein , immunoglobulin g , serum albumin , univariate analysis , gastroenterology , inflammation , multivariate analysis
Aim The role of noninvasive biologic markers for disease activity is very important in children with C rohn's disease. The aim of this study was to assess an association between disease activity and quantitative serum anti‐ Saccharomyces cerevisiae antibody ( ASCA ) titres. Methods Anti‐ Saccharomyces cerevisiae antibody immunoglobulin ( I g) A and immunoglobulin G titres, paediatric C rohn's disease activity index ( PCDAI ), serum albumin and C ‐reactive protein ( CRP ) were repeatedly measured simultaneously in children with C rohn's disease. A possible association between ASCA I g A and I g G titres and changes in PCDAI was examined. Results Serial 136 measurements of ASCA I g A and I g G titres were documented in 57 children with C rohn's disease over a mean duration of 3.1 ± 2.1 years. In a univariate linear regression model, there were significant correlations between ASCA I g A titres and PCDAI (p < 0.001), CRP (p <0.01) and low serum albumin (p < 0.001), respectively. Similarly, ASCA I g G titres significantly correlated with PCDAI , CRP and low serum albumin. Conclusion Both ASCA I g A and I g G titres seemed to correlate well with clinical C rohn's disease activity in children. Measuring these antibodies may be considered during routine clinical care for those patients.