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Codeine should not be prescribed for breastfeeding mothers or children under the age of 12
Author(s) -
Lazaryan Moran,
ShashaZigelman Chen,
Dagan Zachi,
Berkovitch Matitiahu
Publication year - 2015
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.13012
Subject(s) - breastfeeding , medicine , codeine , food and drug administration , agency (philosophy) , breast feeding , adverse effect , pediatrics , family medicine , environmental health , anesthesia , pharmacology , morphine , philosophy , epistemology
Medical regulatory authorities, including the Food and Drug Administration and European Medicine Agency, have published restrictions regarding the use of codeine in paediatric patients and breastfeeding mothers. This review explored the various parameters that are involved in the metabolism and toxicology of codeine in these two populations. Conclusion The growing volume of data on potential serious adverse events and questionable efficacy indicates that codeine should not be prescribed for children under 12 years of age and breastfeeding mothers.