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Incidence and morbidity of urinary tract infection in a prospective cohort of children
Author(s) -
Ladomenou Fani,
Bitsori Maria,
Galanakis Emmanouil
Publication year - 2015
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.12992
Subject(s) - medicine , incidence (geometry) , pediatrics , epidemiology , prospective cohort study , urinary system , retrospective cohort study , cumulative incidence , cohort study , cohort , surgery , physics , optics
Aim Information on the epidemiology of childhood urinary tract infections ( UTI s) is scarce and mostly based on retrospective data. This study investigated incidence rates, morbidity and risk factors for UTI s in a prospective cohort of children. Methods We explored UTI s in a representative cohort of 1049 neonates from birth to 6 years of age, using maternal interviews that were verified by hospital records. The majority (88.2%) completed the first‐year, and more than half (56.2%) completed the 6‐year follow‐up. Results By 6 years of age, more than 10% of our sample had been affected by UTI s. The cumulative incidence for the first year of life was 3.77%, without significant differences between genders, and for one to 6 years, it was 6.81% and 5.7 times higher in girls than boys. Clinical information was available for 63 children: 25 were hospitalised, 16 suffered recurrences, 10 received prophylaxis, eight had urinary tract malformations, three required surgery, and two had impaired renal function. Conclusion UTI s affected approximately 4% and 10% of children by the ages of one and 6 years, respectively, and their incidence was related to gender and age. Morbidity was considerable, recurrences were common, and despite advances in management, long‐term consequences may still be encountered.