Premium
Autism spectrum disorders: linking neuropathological findings to treatment with transcranial magnetic stimulation
Author(s) -
Casanova Manuel F.,
Sokhadze Estate,
Opris Ioan,
Wang Yao,
Li Xiaoli
Publication year - 2015
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.12943
Subject(s) - transcranial magnetic stimulation , autism , neuroscience , medicine , autism spectrum disorder , neuropil , stimulation , psychiatry , psychology , central nervous system
Postmortem studies in autism spectrum disorder ( ASD ) individuals indicate the presence of abnormalities within the peripheral neuropil space ( PNS ) of cortical minicolumns. The geometrical orientation of inhibitory elements within the PNS suggests using repetitive transcranial magnetic stimulation (r TMS ) to up‐regulate their activity. Several r TMS trials in ASD have shown marked improvements in motor symptomatology, attention and perceptual binding. Conclusion: r TMS is the first therapeutic attempt at ASD aimed at correcting some of its core pathology.