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The endocrine disruptor bisphenol A may play a role in the aetiopathogenesis of polycystic ovary syndrome in adolescent girls
Author(s) -
Akın Leyla,
Kendirci Mustafa,
Narin Figen,
Kurtoglu Selim,
Saraymen Recep,
Kondolot Meda,
Koçak Selda,
Elmalı Ferhan
Publication year - 2015
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.12885
Subject(s) - polycystic ovary , medicine , bisphenol a , endocrinology , endocrine system , endocrine disruptor , obesity , testosterone (patch) , bisphenol , insulin resistance , population , hormone , chemistry , environmental health , organic chemistry , epoxy
Aim Experimental in vitro studies have shown that bisphenol A affects steroidogenesis, folliculogenesis and ovarian morphology. The aim of this study was to investigate the role of the endocrine disruptor bisphenol A in the aetiopathogenesis of polycystic ovary syndrome ( PCOS ) in adolescents and its relationship with metabolic parameters, insulin resistance and obesity in this population. Methods A total of 112 girls with PCOS and 61 controls between 13 and 19 years of age were enrolled in the study. Serum bisphenol A levels were measured by high‐pressure liquid chromatography. An oral glucose tolerance test was also performed. Results Adolescents with PCOS had markedly increased serum bisphenol A levels (mean: 1.1 ng/mL 95% CI : 1.0–1.2) than controls (mean: 0.8 ng/mL 95% CI : 0.6–0.9, p = 0.001). When we compared the subgroups according to obesity, the main factor determining the significant increase in bisphenol A was the presence of PCOS , but not obesity (p = 0.029). Bisphenol A was significantly correlated with total testosterone (r = 0.52), free testosterone (r = 0.44), dehydroepiandrosterone sulphate (r = 0.37) and Ferriman–Gallwey score (r = 0.43) (p < 0.05). Conclusion Adolescents with PCOS had higher serum bisphenol A levels than controls, independent of obesity. Bisphenol A concentrations were significantly correlated with androgen levels, leading us to consider that bisphenol A might play a role in the aetiopathogenesis of PCOS in adolescents.