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Therapeutic hypothermia for hypoxic ischaemic encephalopathy using low‐technology methods: a systematic review and meta‐analysis
Author(s) -
Rossouw Gerhardus,
Irlam James,
Horn Alan R
Publication year - 2015
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.12830
Subject(s) - medicine , hypothermia , encephalopathy , meta analysis , intensive care , intensive care medicine , hypoxia (environmental) , systematic review , anesthesia , medline , political science , law , chemistry , organic chemistry , oxygen
A systematic review and meta‐analysis were performed to determine the effect of therapeutic hypothermia using low‐technology methods, in settings with facilities for intensive care, in term or near‐term infants with hypoxic‐ischaemic encephalopathy on mortality, neurological morbidity at discharge and neurological morbidity at 6–24 months. Conclusion Meta‐analysis of three randomised controlled studies showed that low‐technology therapeutic hypothermia in an intensive care setting significantly reduced the mortality and the neurological morbidity in survivors at discharge.