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Prethreshold retinopathy in premature infants with intrauterine growth restriction
Author(s) -
Lee Jennifer W.,
VanderVeen Deborah,
Allred Elizabeth N.,
Leviton Alan,
Dammann Olaf
Publication year - 2015
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.12799
Subject(s) - medicine , gestational age , odds ratio , retinopathy of prematurity , confounding , confidence interval , logistic regression , intrauterine growth restriction , small for gestational age , obstetrics , birth weight , pediatrics , pregnancy , gestation , genetics , biology
Aim To determine, among very preterm newborns, whether those who are growth‐restricted are at increased risk of retinopathy of prematurity ( ROP ), and to explore whether the mixed findings of prior studies are the consequence of sampling based upon birthweight instead of gestational age. Methods Using data from the ELGAN Study, we created logistic regression models of prethreshold ROP risk to adjust for confounders and calculate odds ratios and 99% confidence intervals. We created scatter plots to display the gestational age/birthweight relationship in infants enrolled in studies with different selection criteria. Results Low gestational age [23–24 weeks, OR 11.6 (2.9, 47); 25–26 weeks, 8.1 (2.1, 32)] and severe growth restriction [birthweight Z‐score <−2, OR 9.1 (1.1, 76)] were associated with increased risk of prethreshold ROP . We documented in scatter plots that a sample defined by birthweight has an excess of gestationally older, severely growth ‐ restricted newborns. Conclusion In this sample, low gestational age and severe growth restriction were associated with increased risk of prethreshold ROP .