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The triglyceride to high‐density lipoprotein ratio identifies children who may be at risk of developing cardiometabolic disease
Author(s) -
Bailey Daniel P.,
Savory Louise A.,
Denton Sarah J.,
Davies Ben R.,
Kerr Catherine J.
Publication year - 2014
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.12677
Subject(s) - medicine , cardiorespiratory fitness , odds ratio , anthropometry , triglyceride , waist , high density lipoprotein , cholesterol , endocrinology , physical therapy , body mass index
Aim It is important to develop simple, reliable methods to identify high‐risk individuals who may benefit from intervention. This study investigated the association between the triglyceride to high‐density lipoprotein cholesterol ( TG / HDL ) ratio and cardiometabolic risk, cardiorespiratory fitness and physical activity in children. Methods Anthropometric, biochemical parameters, cardiorespiratory fitness and accelerometry determined physical activity were assessed in 155 children (80 girls) from 10 to 14 years of age from B edfordshire, UK . Participants were grouped into high and low TG / HDL ratio groups, according to published thresholds. MANCOVA and logistic regression were used in the analysis. Results Cardiometabolic risk factor levels were significantly higher in participants with a high TG / HDL ratio (p < 0.05). The odds of having high waist circumference ( OR = 13.99; 95% CI 2.93, 69.25), elevated systolic blood pressure (5.27; 1.39, 20.01), high non‐ HDL cholesterol (19.47; 4.42, 85.81) and ≥2 cardiometabolic risk factors (15.32; 3.10, 75.79) were higher in participants with a high TG / HDL ratio. The TG / HDL ratio values were significantly lower in those with high cardiorespiratory fitness (p = 0.01), but there was no association with physical activity. Conclusion These findings support the use of the TG / HDL ratio to identify children with cardiometabolic risk factors who may be at risk of developing cardiometabolic disease.