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Raman spectroscopy provides a noninvasive approach for determining biochemical composition of the pregnant cervix in vivo
Author(s) -
O'Brien Christine M.,
Vargis Elizabeth,
Paria Bibhash C.,
Bennett Kelly A.,
MahadevanJansen Anita,
Reese Jeff
Publication year - 2014
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.12630
Subject(s) - cervix , medicine , raman spectroscopy , pregnancy , in vivo , obstetrics , pathology , optics , biology , physics , microbiology and biotechnology , cancer , genetics
The molecular changes that occur with cervical remodelling during pregnancy are not completely understood. This study reviews Raman spectroscopy, an optical technique for detecting changes in the pregnant cervix, and reports preliminary studies on cervical remodelling in mice that suggest that the technique provides advantages over other methods. Conclusion Raman spectroscopy is sensitive to biochemical changes in the pregnant cervix and has high potential as a tool for detecting premature cervical remodelling in pregnant women.