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Population‐based study shows improved postnatal growth in preterm very‐low‐birthweight infants between 1995 and 2010
Author(s) -
Ofek Shlomai Noa,
Reichman Brian,
LernerGeva Liat,
Boyko Valentina,
BarOz Benjamin
Publication year - 2014
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.12569
Subject(s) - medicine , odds ratio , confidence interval , gestational age , pediatrics , birth weight , odds , low birth weight , logistic regression , population , small for gestational age , obstetrics , pregnancy , environmental health , biology , genetics
Abstract Aim To assess whether the postnatal growth of preterm very‐low‐birthweight ( VLBW ) infants, as determined by measures of postnatal growth failure ( PNGF ), improved during the period 1995–2010 and to evaluate postnatal growth by gestational age ( GA ) and intrauterine growth groups. Methods The study was based on the Israel national VLBW infant database and comprised 13 531 VLBW infants of 24–32 weeks' GA , discharged at a postmenstrual age of ≤40 weeks. Z ‐scores were determined for weight at birth and discharge. Severe and mild PNGF was defined as a decrease >2 and 1–2 z ‐scores, respectively. Three time periods were considered: 1995–2000, 2001–2005 and 2006–2010. Multinomial logistic regression was used to assess the independent effect of time period on PNGF . Results Severe PNGF decreased from 11.7% in 1995–2000 to 7.2% in 2001–2005 and 5.2% in 2006–2010. Infants born in 2006–2010 had sixfold lower odds for severe PNGF than babies born in 1995–2000 (adjusted odds ratio 0.17, 95% confidence interval 0.14–0.21) and