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Blood eosinophil counts during bronchiolitis are related to bronchial hyper‐responsiveness and lung function in early adolescence
Author(s) -
Mikalsen Ingvild Bruun,
Halvorsen Thomas,
Øymar Knut
Publication year - 2014
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.12432
Subject(s) - medicine , bronchiolitis , eosinophil , asthma , atopy , immunology , pulmonary function testing , bronchiolitis obliterans , leukotriene , gastroenterology , lung , respiratory system , lung transplantation
Aim To assess whether inflammatory markers measured in urine and blood during acute bronchiolitis in infancy were associated with asthma, lung function, bronchial hyper‐responsiveness ( BHR ) and atopy at 11 years of age. Methods We included 105 children hospitalised for bronchiolitis during their first year of life. At hospitalisation, urinary ( U ‐) eosinophil protein X , U ‐leukotriene E 4 , U‐prostaglandin 9α, 11β‐ PGF 2 and blood eosinophil counts were measured. Ninety‐five children (90%) were available for follow‐up at 11 years of age. Results At follow‐up, higher blood eosinophil counts obtained during bronchiolitis were observed in the group with asthma than in the group without asthma (median 0.27 versus 0.09 × 10 9 /L, respectively, p = 0.048). By regression analyses, blood eosinophil counts during the acute bronchiolitis were positively associated with BHR (p = 0.006) and negatively associated with forced expiratory volume in first second (p = 0.025) at 11 years of age. None of the other inflammatory markers were associated with asthma, lung function, BHR or atopy at 11 years of age. Conclusion Eosinophil inflammation during bronchiolitis may have a long‐term impact on lung function and airway responsiveness. The associations could be related to virus–host interactions during bronchiolitis or to predisposed children.