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Saccharomyces boulardii for prevention of necrotizing enterocolitis in preterm infants: a randomized, controlled study
Author(s) -
Demirel Gamze,
Erdeve Omer,
Celik Istemi Han,
Dilmen Ugur
Publication year - 2013
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.12416
Subject(s) - medicine , saccharomyces boulardii , necrotizing enterocolitis , sepsis , incidence (geometry) , gestational age , birth weight , low birth weight , enterocolitis , randomized controlled trial , pediatrics , probiotic , gastroenterology , pregnancy , genetics , physics , bacteria , optics , biology
Aim To evaluate the efficacy of orally administered S accharomyces boulardii ( S . boulardii ) for reducing the incidence and severity of necrotizing enterocolitis ( NEC ) in very low‐birth‐weight ( VLBW ) infants. Methods A prospective, randomised controlled trial was conducted in infants with gestational age ≤32 weeks and birth weight ≤1500 g. The study group received S . boulardii supplementation, and the control group did not. The primary outcomes were death or NEC (Bell's stage ≥2), and secondary outcomes were feeding intolerance and clinical or culture‐proven sepsis. Results A total of 271 infants were enrolled in the study, 135 in the study group and 136 in the control group. There was no significant difference in the incidence of death (3.7% vs. 3.6%, 95% CI of the difference, −5.20–5.25; p = 1.0) or NEC (4.4% vs. 5.1%, 95% CI , −0.65–5.12; p = 1.0) between the groups. However, feeding intolerance and clinical sepsis were significantly lower in the probiotic group compared with control. Conclusion Although S accharomyces boulardii supplementation at a dose of 250 mg/day was not effective at reducing the incidence of death or NEC in VLBW infants, it improved feeding tolerance and reduced the risk of clinical sepsis.