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The role of the human leukocyte antigen system in retinopathy of prematurity: a pilot study
Author(s) -
FlordeLima Filipa,
Rocha Gustavo,
Proença Elisa,
Tafulo Sandra,
Freitas Fátima,
Guimarães Hercília
Publication year - 2013
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.12410
Subject(s) - retinopathy of prematurity , medicine , gestational age , univariate analysis , human leukocyte antigen , retinopathy , birth weight , population , pediatrics , multivariate analysis , immunology , pregnancy , antigen , endocrinology , genetics , diabetes mellitus , biology , environmental health
Aim To assess the association between the human leukocyte antigen system and retinopathy of prematurity. Methods Neonates of <32 weeks of gestational age, born at two level III neonatal intensive care units from J anuary 2000 to D ecember 2001 and from J anuary 2006 to June 2009, were included in the study. Demographic and clinical data were recorded, and retinopathy was classified according to the International Classification. Epithelial cells were collected from the oral cavity and the HLA were studied using the PCR / SSO method. Univariate and multivariate analyses were performed using SPSS® v.18. Results We evaluated 156 neonates, including 82 (52.6%) males. Median gestational age was 29 (23–31) weeks, and median birth weight was 1030 (525–1935) grams. Seventy (44.9%) of the neonates developed retinopathy. Alleles HLA ‐ B *38, HLA ‐ C w*12, HLA ‐ DRB 1*09, HLA ‐ DRB 1*14 (univariate analysis) and HLA ‐ A *68 and HLA ‐ C w*12 were associated to retinopathy (multivariate analysis). Conclusion The results suggest that the HLA system may be associated with the development of retinopathy of prematurity. A large‐scale population‐based study should be performed to clarify this association.