Monitoring D oppler patterns and clinical parameters may predict feeding tolerance in intrauterine growth‐restricted infants

Aim To detect predictors of feeding tolerance in intrauterine growth restriction ( IUGR ) infants with or without brain‐sparing effect ( BS ). Methods We conducted a case–control study in 70 IUGR infants (35 IUGR with BS , matched for gestational age with 35 IUGR infants with no BS ). BS was classified as pulsatility index ( PI ) ratio [umbilical artery ( UAPI ) to middle cerebral artery ( MCAPI ) ( U / C ratio)] > 1. Clinical parameters of feeding tolerance – days to achieve full enteral feeding ( FEF ) – were compared between the IUGR with BS and IUGR without BS infants. Age at the start of minimal enteral feeding ( MEF ) was analysed. Results Achievement of FEF was significantly shorter in IUGR infants without BS than in IUGR with BS . IUGR with BS started MEF later than IUGR without BS infants. Significant correlation of MEF and FEF with UA PI , U / C ratio and CRIB score was found. Multiple linear regression analysis showed significant correlations with CRIB score and caffeine administration ( MEF only), and sepsis ( FEF only) and U / C ratio (for both). Conclusion Impaired gut function can be early detected by monitoring D oppler patterns and clinical parameters.