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Monitoring D oppler patterns and clinical parameters may predict feeding tolerance in intrauterine growth‐restricted infants
Author(s) -
Bozzetti Valentina,
Paterlini Giuseppe,
Gazzolo Diego,
Bel Frank,
Visser Gerard HA,
Roncaglia Nadia,
Tagliabue Paolo E
Publication year - 2013
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.12380
Subject(s) - medicine , intrauterine growth restriction , enteral administration , umbilical artery , gestational age , sepsis , parenteral nutrition , obstetrics , pregnancy , fetus , genetics , biology
Aim To detect predictors of feeding tolerance in intrauterine growth restriction ( IUGR ) infants with or without brain‐sparing effect ( BS ). Methods We conducted a case–control study in 70 IUGR infants (35 IUGR with BS , matched for gestational age with 35 IUGR infants with no BS ). BS was classified as pulsatility index ( PI ) ratio [umbilical artery ( UAPI ) to middle cerebral artery ( MCAPI ) ( U / C ratio)] > 1. Clinical parameters of feeding tolerance – days to achieve full enteral feeding ( FEF ) – were compared between the IUGR with BS and IUGR without BS infants. Age at the start of minimal enteral feeding ( MEF ) was analysed. Results Achievement of FEF was significantly shorter in IUGR infants without BS than in IUGR with BS . IUGR with BS started MEF later than IUGR without BS infants. Significant correlation of MEF and FEF with UA PI , U / C ratio and CRIB score was found. Multiple linear regression analysis showed significant correlations with CRIB score and caffeine administration ( MEF only), and sepsis ( FEF only) and U / C ratio (for both). Conclusion Impaired gut function can be early detected by monitoring D oppler patterns and clinical parameters.