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Perinatal systemic inflammatory responses of growth‐restricted preterm newborns
Author(s) -
McElrath TF,
Allred EN,
Van Marter L,
Fichorova RN,
Leviton A
Publication year - 2013
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.12339
Subject(s) - medicine , systemic inflammation , systemic inflammatory response syndrome , growth retardation , pediatrics , intensive care medicine , pregnancy , inflammation , immunology , sepsis , genetics , biology
Abstract Aim To compare the early post‐natal pattern of systemic inflammation in growth‐restricted infants born before the 28th week of gestation to that of appropriately grown peers. Methods We measured the concentrations of 25 inflammation‐related proteins in blood spots collected from 939 newborns during the first 2 post‐natal weeks. We calculated the odds ratios (99% confidence intervals) that concentrations would be in the highest quartile. Results Severely growth‐restricted infants (birth weight Z ‐score <−2) were not at increased risk of systemic inflammation shortly after birth. On post‐natal day 14, however, they were significantly more likely than their peers to have a CRP , IL ‐1β, IL ‐6, TNF ‐α, IL ‐8, MCP ‐4, ICAM ‐1, ICAM ‐3, E‐ SEL , MMP ‐9, VEGF ‐R2 and/or IGFBP ‐1 concentration in the highest quartile. These increased risks could not be attributed to delivery indication, bacteremia or duration of ventilation. Conclusion Growth‐restricted preterm newborns appear to be at increased risk of elevated concentrations of inflammation‐associated proteins by post‐natal day 14.