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Urinary angiotensinogen as a novel marker of obstructive nephropathy in children
Author(s) -
TarantaJanusz Katarzyna,
Wasilewska Anna,
Dębek Wojciech,
Fiłonowicz Renata,
MichalukSkutnik Joanna
Publication year - 2013
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.12324
Subject(s) - medicine , urinary system , hydronephrosis , urology , renal function , nephropathy , cohort , differential diagnosis , gastroenterology , pathology , endocrinology , diabetes mellitus
Aim Obstructive nephropathy due to congenital or acquired urinary tract obstruction is one of the most important causes of chronic renal failure in children. There is a need for identification of new noninvasive urinary biomarkers to provide the clinician with fast, specific and reliable diagnostic and prognostic tool. The aim of the study was to determine whether urinary angiotensinogen ( uAGT ) may be a useful marker of obstruction in children with hydronephrosis (HN) caused by ureteropelvic junction obstruction (UPJO). Methods The study cohort consisted of surgical group (SG): 31 children with severe HN who required surgery; nonsurgical group (NSG): 20 patients with mild HN, and reference group (RG): 19 healthy children. Urinary concentrations of angiotensinogen were measured using immunoenzymatic ELISA commercial kit and were expressed in ng/mg Cre ( uAGT / uC re). Results uAGT / uC re level was higher in SG when compared to NSG (p < 0.01) and healthy participants (SG vs. RG: p < 0.01). The difference between the uAGT / uC re in NSG and RG was not statistically significant (p > 0.05). uAGT / uC re was correlated negatively with differential renal function (r = −0.46; p < 0.01). Conclusion The present pilot study has clearly demonstrated that children with UPJO showed increased uAGT levels, which correlated negatively with differential renal function in radionuclide scan.