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Apparent diffusion coefficient values predict outcomes of abusive head trauma
Author(s) -
Tanoue Koji,
Aida Noriko,
Matsui Kiyoshi
Publication year - 2013
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.12281
Subject(s) - white matter , medicine , corpus callosum , grey matter , effective diffusion coefficient , head trauma , basal ganglia , pediatrics , diffusion mri , surgery , magnetic resonance imaging , pathology , central nervous system , radiology
Aim To evaluate the apparent diffusion coefficient ( ADC ) values for predicting the long‐term neurodevelopmental outcomes of patients with abusive head trauma ( AHT ). Methods Apparent diffusion coefficient maps were retrospectively reviewed for 14 patients who presented with AHT at a mean age of 6.7 months (range 1–18 months), and the clinical outcomes of the survivors were based on the G lasgow O utcome S core. Results One of 14 infants died, and two were severely disabled. One had mild impairment and four had moderate disability. In the 4 days after admission, the ADC values in all brain regions were strongly associated with a poor neurodevelopmental outcome (p < 0.05): basal ganglia, thalamus, brain stem, corpus callosum, frontal white matter, central white matter, parietal white matter, frontal grey matter, parietal grey matter, cerebellar vermis, cerebellar cortex and mean total brain. Conclusion Apparent diffusion coefficient values during the acute phase of AHT were significantly associated with poor long‐term neurodevelopmental outcomes.