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Childhood lung function and the association with β2‐adrenergic receptor haplotypes
Author(s) -
Torjussen Tale M,
MuntheKaas Monica C,
Mowinckel Petter,
Carlsen KaiHåkon,
Undlien Dag E,
Lødrup Carlsen Karin C
Publication year - 2013
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.12221
Subject(s) - haplotype , medicine , single nucleotide polymorphism , prospective cohort study , lung , lung function , pulmonary function testing , tobacco smoke , cohort , genotype , pediatrics , physiology , genetics , gene , biology , environmental health
Aim To determine associations between ADRB 2 polymorphisms and lung function through childhood, and possible modification by gender, pet keeping or tobacco smoke. Methods Four ADRB 2 single nucleotide polymorphisms (rs1042711, rs1042713, rs1042714 and rs1800888) were genotyped in 953 children from the prospective birth cohort ‘ E nvironment and C hildhood A sthma’ study and analysed for association with flow‐volume parameters at birth (tidal breathing) and at 10 years of age (maximally forced), stratified by environmental exposures. Results The risk of reduced lung function was reduced in 10‐year‐old children carrying the most common ADRB 2 haplotype ( CGGC ) ( OR 0.45 (95% CI 0.25, 0.82)), whereas there was no association between lung function at birth and ADRB 2 haplotypes. Tobacco smoke exposure, gender and pet keeping did not significantly interact with the haplotypes in influencing lung function. Conclusion This study demonstrates a possible protective effect by the ADRB 2 haplotype I ( CGGC ) on reduced FEV 1 in 10‐year‐old children, whereas no ADRB 2 geno‐/haplotypes were significantly associated with neonatal lung function. The ADRB 2 gene thus appears to contribute to lung function development in childhood, independently of smoking, pets and gender.