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Does cow's milk protein elimination diet have a role on induction and maintenance of remission in children with ulcerative colitis?
Author(s) -
Strisciuglio Caterina,
Giannetti Eleonora,
Martinelli Massimo,
Sciorio Elisa,
Staiano Annamaria,
Miele Erasmo
Publication year - 2013
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.12215
Subject(s) - medicine , elimination diet , mesalazine , ulcerative colitis , randomized controlled trial , concomitant , maintenance therapy , gastroenterology , pediatrics , allergy , immunology , chemotherapy , disease , food allergy
Aim Aims of this study were to evaluate the efficacy of a cow's milk protein ( CMP ) elimination diet on induction and maintenance of remission and to define association with atopy in children with ulcerative colitis ( UC ). Methods Twenty‐nine consecutive patients (mean age: 11.2 years; range: 4.6–17 years; F/M: 15/14) with newly diagnosed UC were randomized either to receive a CMP elimination diet (n = 14) or to continue a free diet (n = 15) associated with concomitant steroid induction and mesalazine maintenance treatment. Children were prospectively evaluated at four time points: within 1 month, 6 months and 1 year after diagnosis or at the time of relapse. Results Twenty‐five of the 29 enrolled patients responded to the UC induction therapy with a complete remission (86.2%), 13 belonging to CMP elimination diet group and 12 to free diet group (p = 0.59). Overall, our data showed that 7 of 13 (53.8%) patients treated with CMP elimination diet and 8 of 15 (53.3%) patients on free diet and UC therapy relapsed within 1 year of follow‐up (p = 1). Conclusions In conclusion, data of this paediatric, randomized trial suggest that CMP elimination has no role in the management of UC in non‐sensitized children.