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Visceral fat accumulation and metabolic syndrome in children: the impact of T rp64 A rg polymorphism of the beta3‐adrenergic receptor gene
Author(s) -
Oguri Kazuo,
Tachi Toshiki,
Matsuoka Toshio
Publication year - 2013
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.12149
Subject(s) - medicine , endocrinology , triglyceride , blood pressure , metabolic syndrome , lipoprotein , lipid profile , diastole , fat mass , lipid metabolism , obesity , cholesterol
Aim To investigate the association between T rp64 A rg polymorphism of the beta3‐adrenergic receptor ( ADRB3 ) gene and total fat mass, abdominal fat distribution, other metabolic derangements and metabolic syndrome ( MS ) in J apanese children. Methods Molecular screening of the ADRB3 gene polymorphism ( T rp64 T rp, T rp64 A rg and A rg64 A rg) was carried out in 132 children aged 6–12 years: 73 were obese (45 boys) and 59 were not obese (27 boys). Visceral fat ( VF ) and subcutaneous fat ( SF ) area were measured using magnetic resonance imaging, blood pressure, lipid and glucose profiles. Results The frequencies of A rg carriers ( T rp64 A rg or A rg64 A rg) were significantly higher in obese children with MS , compared to obese children without MS and nonobese children. In obese children, A rg carriers had significantly higher VF area, systolic and diastolic blood pressure, and low‐density lipoprotein cholesterol and triglyceride than A rg noncarriers ( T rp64 T rp). However, there were no differences in total fat mass and SF area between the two groups. In nonobese children, none of these parameters differed significantly between A rg carriers and noncarriers. Conclusion T rp64 A rg polymorphism of the ADRB3 gene may affect VF accumulation and be associated with MS , a cluster of conditions involving aggravated lipid metabolism and higher blood pressure, in J apanese children.