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Neurodevelopment in children with and without congenital heart block born to anti‐Ro/ SSA ‐positive mothers
Author(s) -
Skog Amanda,
Tingström Joanna,
Salomonsson Stina,
Sonesson SvenErik,
WahrenHerlenius Marie
Publication year - 2013
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.12049
Subject(s) - medicine , pediatrics , heart block , cardiology , electrocardiography
Objective To define factors influencing neurodevelopment in children with and without complete congenital heart block ( CHB ) born to mothers with Ro/ SSA autoantibodies. Patients and methods Medical records of a population‐based cohort of siblings with (n = 60) and without (n = 54) CHB born 1974–2009 to anti‐Ro/ SSA ‐positive mothers were retrieved from children primary healthcare centres and school health services and used to extract data on neurodevelopment. Results Impaired neurodevelopment was reported in 16% of the children (18/114) during the follow‐up time of 13.0 (8.2–17.5) years, median (quartiles). Reported problems included speech (9%), motor (8%) and learning (8%) impairment, attention deficit (5%) and behavioural impairment (4%). Impairment in motor skill development was more common in boys (p < 0.001) if the child was born preterm (p < 0.001). Learning impairment was significantly influenced by maternal SLE (p < 0.005), while attention deficits was influenced by both maternal SLE (p < 0.05) and CHB in the child (p < 0.05). Conclusions Our data indicate that in addition to well‐established factors such as male sex and being born preterm, both maternal SLE and CHB may influence neurodevelopment. Follow‐up of neurodevelopment should therefore be considered for children with CHB , especially if the mother is diagnosed with SLE .