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Neurodevelopmental outcome at 6 years of age after intrauterine laser therapy for twin‐twin transfusion syndrome
Author(s) -
Graeve Pauline,
Banek Corinna,
StegmannWoessner Gaby,
Maschke Cornelia,
Hecher Kurt,
Bartmann Peter
Publication year - 2012
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.12017
Subject(s) - medicine , twin twin transfusion syndrome , laser therapy , pediatrics , transfusion therapy , twin to twin transfusion syndrome , blood transfusion , obstetrics , pregnancy , surgery , fetus , laser , genetics , biology , physics , optics
This study was undertaken to evaluate neurodevelopmental outcome of children at 6 years of age after intrauterine laser therapy for Twin‐twin transfusion syndrome (TTTS). This is part of a longitudinal study in children after intrauterine laser therapy for TTTS; 190 of 254 (74.8%) children, previously investigated at a median age of 2 years 10 months, were re‐evaluated at 6 years 5 months (range 4 years 11 months –10 years 4 months). Sixty‐four patients were not examined due to loss of contact. The median gestational age at birth was 34 + 3 weeks. The study included a physical/neurological examination, a standardized neurodevelopmental test (Kaufman‐ABC) and/or results from the national screening programme for children as well as questionnaires. Patients were grouped in three outcome categories: group I: normal examination and test result; group II: minor neurological deficiencies and normal test results; group III: major neurological deficiencies and/or test results below minus two standard deviations. The following results were obtained at 6 years 5 months (for comparison, results of the same patients at 2 years 10 months in brackets). Group I: 79.5% (84.2%); group II: 11.6% (8.9%); group III: 8.9% (6.8%). Twenty‐one (11%) patients had a worse and 8 (4.2%) an improved classification at 6 years 5 months as compared to 2 years 10 months. Overall, the results with 6 years did not significantly differ from the results with 2 years. Neurodevelopmental outcome at 6 years 5 months was not statistically, significantly different from outcome at 2 years 10 months.