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Vascular risk factors for optical coherence tomography‐detected macular cysts: The Maastricht Study
Author(s) -
De Clerck Eline E. B.,
Schouten Jan S. A. G.,
Berendschot Tos T. J. M.,
Goezinne Fleur,
Liesenborghs Ilona,
Dagnelie Pieter C.,
Schaper Nicolaas C.,
Kroon Abraham A.,
Henry Ronald M. A.,
Reesink Koen D.,
Schram Miranda T.,
Stehouwer Coen D. A.,
Webers Carroll A. B.
Publication year - 2021
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.14677
Subject(s) - medicine , blood pressure , pulse wave velocity , pulse pressure , optical coherence tomography , arterial stiffness , diabetes mellitus , cardiology , type 2 diabetes , ophthalmology , endocrinology
Purpose To investigate whether higher blood pressure and greater arterial stiffness are associated with the presence of macular cysts and whether this association is already present in the absence of micro‐aneurysms in individuals with and without type 2 diabetes. Methods Using spectral domain optical coherence tomography (OCT), we performed a macular volume scan in 2647 individuals (mean age 60 ± 8 years, 50% men, 27% type 2 diabetes). The association between macular cysts and 24‐hour systolic and diastolic blood pressure, pulse pressure, mean arterial blood pressure, carotid‐femoral pulse wave velocity and carotid distensibility was assessed by use of logistic regression. Results Twenty‐four hours systolic blood pressure was associated with the presence of macular cysts [OR = 1.03 (95% CI 1.00–1.05) per 1 mmHg, p = 0.03]. 24 hr pulse pressure [OR = 1.61 (95% CI 1.11–2.34) per 10 mmHg, p = 0.01] and carotid‐femoral pulse wave velocity [OR = 1.16 (95% CI 1.02–1.32) per 1 m/s, p = 0.02] were associated with macular cysts, while carotid distensibility was not [OR = 1.03 (95% CI 0.96–1.11) per 1.0*10 −3 /kPa, p = 0.45]. Associations were similar in individuals with and without type 2 diabetes and were already present in the absence of micro‐aneurysms. Conclusion Twenty‐four hours systolic blood pressure, 24 hr pulse pressure and carotid‐femoral pulse wave velocity are associated with the presence of OCT‐detected macular cysts in individuals with and without type 2 diabetes, even in the absence of micro‐aneurysms. Therefore, blood pressure and aortic stiffness are potential factors contributing to macular cysts.