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Effect of preoperative topical nepafenac 0.1% on inflammatory response after uncomplicated cataract surgery in healthy subjects
Author(s) -
Cagini Carlo,
Cerquaglia Alessio,
Pellegrino Adriana,
Ian Alessia,
Lupidi Marco,
Fiore Tito
Publication year - 2021
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.14513
Subject(s) - medicine , cataract surgery , intraocular pressure , randomized controlled trial , surgery , ophthalmology , prospective cohort study , visual acuity , anesthesia
Purpose To determine the effect of preoperative topical Nepafenac administration on anterior chamber flare after uneventful cataract surgery in healthy subjects. Methods Prospective randomized clinical trial. Seventy‐three eyes of 73 healthy patients undergoing routine cataract surgery were randomized to receive (group A) topical nepafenac (1 mg/ml) or not to receive (group B) 1 drop 3 times per day for 3 days before surgery. All eyes received the same postoperative anti‐inflammatory therapy. Clinical outcome parameters such as best corrected visual acuity, intraocular pressure, retinal central foveal thickness and aqueous flare were recorded preoperatively, 1, 15, 30 and 60 days after surgery. Results Three patients were excluded for poor compliance, and three patients were excluded or developing pseudophakic macular oedema during the follow‐up. Both groups were comparable for age, gender, and showed similar BCVA, intraocular pressure and central macular thickness values preoperatively and during the entire follow‐up (p > 0.01). Aqueous flare values showed a statistically increase in both groups respect to preoperative values through follow‐up evaluations (p < 0.01), while values were significantly lower in group A than in group B 30 days after surgery (p < 0.01). Conclusion Preoperative administration of topical Nepafenac reduces the inflammatory response in healthy patients undergoing uncomplicated cataract surgery one month after surgery respect to non‐treated group.