Premium
Retinal vessel oxygen saturation in patients with unilateral internal carotid artery stenosis: a pilot study
Author(s) -
Zhang Wenbo,
Li Liangliang,
Zou Da,
Ren Qiushi,
Zhang Yadi,
Kang Lei,
Gu Xiaopeng,
Wu Hailong,
Zhang Shijie,
Zhu Ruilin,
Zhang Yanzhen,
Yang Liu
Publication year - 2021
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.14503
Subject(s) - medicine , retinal , oxygen saturation , retinal artery , ophthalmology , internal carotid artery , stenosis , hemodynamics , cardiology , oxygen , chemistry , organic chemistry
Purpose To investigate the retinal vessel oxygen saturation in patients with internal carotid artery stenosis (ICAS). Methods This is a cross‐sectional study. Sixteen patients with unilateral moderate or worse ICAS (≥50%) and no fundus diseases were included in the study. Sixteen gender‐ and age‐matched healthy subjects were selected as controls. The mean oxygen saturation and vessel diameters of the retinal arterioles and venules were obtained using a dual‐wavelength spectrophotometric retinal oximeter. Results In the eye of the stenotic side, the retinal vessel oxygen saturation was 100.14 ± 10.27% in the arterioles and 56.50 ± 10.79% in the venules, and the arteriovenous (A‐V) difference was 43.63 ± 7.71%. In the eye of the contralateral side, the oxygen saturation was 96.55 ± 7.50% in the arterioles and 57.42 ± 9.84% in the venules, and the A‐V difference was 39.39 ± 6.33%. In healthy subjects, the oxygen saturation was 93.22 ± 5.98% in the arterioles and 56.57 ± 7.05% in the venules, and the A‐V difference was 36.65 ± 7.33%. The arteriolar oxygen saturation in the stenotic side was higher than that in the contralateral side (p = 0.025) and that in the healthy subjects (p = 0.027), and the A‐V difference in the stenotic side was significantly higher than that in the contralateral side (p = 0.009) and that in the healthy subjects (p = 0.013). The diameters of the arterioles in the stenotic side were smaller than those in the healthy subjects (p = 0.030). Conclusions Patients with ICAS had decreased retinal arteriole diameters and increased retinal vessel oxygen saturation in the arterioles and A‐V differences, suggesting the presence of microcirculation disorder and hyperoxia in the retina.