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Using 24‐hr ocular dimensional profile recorded with a sensing contact lens to identify primary open‐angle glaucoma patients with intraocular pressure constantly below the diagnostic threshold
Author(s) -
Shioya Satomi,
Higashide Tomomi,
Tsuchiya Shunsuke,
SimonZoula Sonja,
Varidel Thierry,
Cerboni Sacha,
Mansouri Kaweh,
Sugiyama Kazuhisa
Publication year - 2020
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.14453
Subject(s) - cls upper limits , medicine , ophthalmology , intraocular pressure , glaucoma , contact lens , normal tension glaucoma , open angle glaucoma
Purpose To evaluate the use of a 24‐hr ocular dimensional profile recorded with a contact lens sensor (CLS) combined with a single tonometric intraocular pressure (IOP) reading to indicate the potential for exceeding the diagnostic threshold for normal tension glaucoma (NTG) in Japanese patients. Methods Intraocular pressure (IOP) of untreated Japanese NTG patients was measured with tonometry every 3 hr from 9:00 to 24:00. The subsequent day a 24‐hr CLS (SENSIMED Triggerfish, Sensimed AG, Lausanne, Switzerland) profile was recorded on the same eye. Patients initially diagnosed as NTG were reclassified as NTG when the measured IOP values were consistently <20 mmHg or as primary open‐angle glaucoma (POAG) when IOP was ≥20 mmHg in at least 1 measurement. For each patient and each IOP time‐point, IOP values were combined with information provided by the CLS profile (‘classifier’) to indicate the potential for exceeding the diagnostic threshold value. Statistical analyses were performed for each classifier. Results A total of 65 patients, 28 males and 37 females (mean ages: 50.8 ± 14.6 years and 52.6 ± 10.2 years, respectively), were analysed. Following IOP diurnal measurement, five patients (7.7%) were reclassified as POAG. Two classifiers (15:00 CLS and 18:00 CLS) showed high sensitivity and negative predictive value (100%), identifying all the POAG patients. Conclusion Contact lens sensor information can be used in conjunction with a single tonometric reading to determine patients’ potential of having IOP levels exceeding the diagnostic threshold within a 24‐hr period, without the need to perform a 24‐hr tonometric curve. This would allow clinicians to identify POAG patients who may otherwise be eventually misclassified as NTG.