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Coronary artery bypass surgery independently associates with retinal vascular oxygen saturation
Author(s) -
Dinesen Sebastian,
Jensen Pia S.,
Bloksgaard Maria,
Mey Jo De,
S.Lindholt Jes,
Rasmusssen Lars M.,
Grauslund Jakob
Publication year - 2020
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.14444
Subject(s) - medicine , retinal , cardiology , artery , bypass grafting , retinal artery , oxygen saturation , coronary artery disease , microcirculation , coronary artery bypass surgery , ophthalmology , oxygen , chemistry , organic chemistry
Purpose The retinal vasculature is the only part of the microcirculation that can be directly studied by non‐invasive imaging. Based on the hypothesis that the systemic circulation is reflected in retinal vessels, we investigated if coronary artery bypass grafting (CABG) is related to changes in retinal vascular oxygen saturation (rSatO 2 ). Methods Retinal metabolism was evaluated by Oxymap T1, which simultaneously captures two retinal images at different wavelengths measuring the retinal arteriolar (raSatO 2 ) and venular (rvSatO 2 ) oxygen saturation. Three to 4 days after surgery, we measured the median rSatO 2 after CABG in 38 patients and in 39 healthy controls (operated for cataract). Results Coronary artery bypass grafting patients had higher raSatO 2 (median ± standard deviation 93.1 ± 6.7% versus 90.5 ± 11.2%, p = 0.001) and rvSatO 2 (57.4 ± 8.3% versus 53.5 ± 15.4%, p = 0.048) compared to healthy controls. In multivariable linear regression models, raSatO 2 independently associated with CABG (coefficient + 3.6% in CABG patients, p = 0.007), and rvSatO 2 correlated with gender (coefficient + 9.4% for females, p = 0.001) and CABG (coefficient + 8.2% in patients with CABG, p = 0.001). Conclusions Comparing patients with and without cardiovascular disease, raSatO 2 and rvSatO 2 positively and independently associated with CABG, suggesting their potential as non‐invasive markers for coronary large artery disease.