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The optic nerve head vasoreactive response to systemic hyperoxia and visual field defect progression in open‐angle glaucoma, a pilot study
Author(s) -
Kiyota Naoki,
Shiga Yukihiro,
Yasuda Masayuki,
Aizawa Naoko,
Omodaka Kazuko,
Tsuda Satoru,
Pak Kyongsun,
Kunikata Hiroshi,
Nakazawa Toru
Publication year - 2020
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.14361
Subject(s) - glaucoma , medicine , optic nerve , visual field , hyperoxia , open angle glaucoma , ophthalmology , blood flow , speckle pattern , intraocular pressure , lung , artificial intelligence , computer science
Purpose To investigate the effect of optic nerve head (ONH) tissue vasoreactivity on glaucoma visual field defect progression. Methods This prospective, longitudinal study comprised 28 eyes of 16 patients with open‐angle glaucoma. Baseline data were obtained from oxygen inhalation testing, including laser speckle flowgraphy measurements of tissue‐area mean blur rate (MT), which represents ONH tissue blood flow, and the mean percentage change in MT (MT‐change). Follow‐up data were collected for at least 2 years, including at least 5 reliable visual field tests. The average total deviation (TD) was calculated in each sector of the Garway‐Heath map; in this study, superior, central and inferior TD corresponded to inferior, temporal and superior MT or MT‐change, respectively. MT and MT‐change in three sectors per eye were included as explanatory variables in a multivariable linear mixed‐effects model, with TD slope set as the response variable. Results At baseline, lower MT and higher diastolic blood pressure were associated with lower MT‐change (p < 0.05). Additionally, MT‐change significantly contributed to TD slope in the corresponding sectors (β = 0.41, p = 0.01). Conclusions Weaker ONH tissue vasoreactivity to systemic hyperoxia, assessed with laser speckle flowgraphy, was associated with lower baseline ONH tissue blood flow, higher diastolic blood pressure and rapid visual field defect progression. Laser speckle flowgraphy variables during oxygen provocation testing may represent potentially useful predictive biomarkers of glaucoma progression.