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Pupillary light responses in type 1 and type 2 diabetics with and without retinopathy
Author(s) -
BaAli Shakoor,
Brøndsted Adam Elias,
Andersen Henrik Ullits,
Jennum Poul,
LundAndersen Henrik
Publication year - 2020
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.14348
Subject(s) - melanopsin , pupillometry , pupil , pupillary response , ophthalmology , medicine , pupillary light reflex , diabetic retinopathy , endocrinology , diabetes mellitus , psychology , retinal , neuroscience , photopigment
Objective We assessed the function of rod/cones and melanopsin in type 1 (T1 DM ) and type 2 diabetes mellitus (T2 DM ) with and without non‐proliferative diabetic retinopathy ( NPDR ). Methods We performed pupillometry on 22 healthy controls and four diabetic groups: 12 T1 DM patients without NPDR and 12 with moderate NPDR , and 16 T2 DM patients without NPDR and 12 with moderate NPDR . Monocular stimulations of 20 seconds with red ( λ = 6 33 nm) and blue light ( λ = 4 63 nm) at ~15 log quanta/cm 2 /second were performed. The primary outcome was the melanopsin‐mediated late redilation phase of postillumination pupillary light response ( PIPR L ate ) to blue light. The secondary outcomes were the mixed rod/cone and melanopsin responses, that is maximal pupil constriction and the early redilation phase of PIPR ( PIPR E arly ). Results Late redilation phase of PIPR ( PIPR L ate ) to blue and red light stimuli was not significantly different between healthy control and the four diabetic groups (n.s.). The maximal pupil contractions to blue light stimulus were significantly reduced in T1 DM patients as well as in T2 DM patients with NPDR (p ≤ 0.02), whereas for red light stimuli, the maximal pupil constriction was only reduced in T2 DM with NPDR (p < 0.01). Early redilation phase of PIPR ( PIPR E arly ) to blue and red light stimuli was not significantly different between healthy controls and diabetic patients (n.s.). Conclusion Neither the PIPR E arly nor the PIPR L ate was significantly reduced in diabetics with or without NPDR compared to healthy controls. The reduced maximal pupil constrictions in diabetics with NPDR indicate decreased mixed rod/cone and melanopsin responses.