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Retinal microvasculature in pituitary adenoma patients: is optical coherence tomography angiography useful?
Author(s) -
Dallorto Laura,
Lavia Carlo,
Jeannerot ArnaudLouis,
Shor Natalia,
Jublanc Christel,
Boch AnneLaure,
Bodaghi Bahram,
Tadayoni Ramin,
Touitou Valérie,
Bonnin Sophie
Publication year - 2020
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.14322
Subject(s) - medicine , pituitary adenoma , ophthalmology , retinal , ganglion , optic nerve , optical coherence tomography , neurovascular bundle , nerve fibre layer , optic neuropathy , adenoma , surgery , pathology , anatomy
Purpose To examine retinal vascular changes in the peripapillary and macular areas in patients with pituitary adenoma ( PA ) using optical coherence tomography angiography ( OCTA ). Methods Cross‐sectional, retrospective study of 17 consecutive PA patients and 16 healthy subjects. All patients underwent a neuro‐ophthalmological examination to assess the presence of optic neuropathy ( ON ). Static automated perimetry ( SAP ), macular and optic disc structural OCT [retinal nerve fibre layer ( RNFL ) and ganglion cell complex ( GCC ) thicknesses] and OCTA were performed. Pituitary adenoma ( PA ) patients with ON were compared to those without ON and to healthy subjects. Results Optic neuropathy ( ON ) was found in 16 eyes of nine PA patients. Peripapillary vessel density (ppVD) and macular vessel density ( VD ) in the superficial vascular plexus were significantly decreased in PA eyes with ON , compared to healthy eyes (45.21 ± 5.69 versus 50.52 ± 2.14% and 43.79 ± 5.03% versus 48.96 ± 2.94%, respectively). No significant difference in VD was observed in the macular deep vascular complex ( DVC ) between groups. Pituitary adenoma ( PA ) patients with ON had a mean pp VD reduction by 10.51% compared to healthy subjects. RNFL and GCC thicknesses were significantly reduced in PA eyes with ON compared to the other groups. Peripapillary VD (ppVD) significantly correlated with RNFL thickness and SAP mean deviation. Conclusions Optical coherence tomography angiography showed a significant decrease in pp VD and superficial macular VD in PA eyes with ON compared to healthy eyes, according to RNFL and GCC thinning. Together with the absence of DVC alterations, it may provide further insights into neurovascular coupling.