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Longitudinal changes in the thickness of the ganglion cell–inner plexiform layer in patients with hypertension: a 4‐year prospective observational study
Author(s) -
Lee Woo Hyuk,
Lee MinWoo,
Lim HyungBin,
Kim KyeungMin,
Shin YongIl,
Kim JungYeul
Publication year - 2020
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.14291
Subject(s) - medicine , observational study , inner plexiform layer , ophthalmology , prospective cohort study , multivariate analysis , multivariate statistics , bayesian multivariate linear regression , univariate analysis , univariate , ganglion , linear regression , retinal , mathematics , anatomy , statistics
Purpose Hypertension ( HTN ) is expected to accelerate age‐related ganglion cell–inner plexiform layer thickness ( GC ‐ IPL s) reduction, but there is limited information on the reduction rate of GC ‐ IPL s in HTN patients. We investigate longitudinal changes in the thickness of GC ‐ IPL in patients with HTN . Methods We performed a prospective, longitudinal and observational study design. Participants were divided into two groups: HTN group (49 eyes) and control group (56 eyes). After the initial visit, GC ‐ IPL s were measured four times at 1‐year intervals using spectral‐domain optical coherence tomography. The GC ‐ IPL reduction rate was estimated using a linear mixed model and compared between the two groups. Univariate and multivariate generalized linear mixed models were used to identify factors associated with reductions in GC ‐ IPL s over time. Results In a linear mixed model, the GC ‐ IPL reduction rates for the HTN and control groups were −0.64 (p < 0.001) and −0.19 (p < 0.001) μ m/year, respectively, and the interaction between group and follow‐up duration was significant (p < 0.001). In the HTN group, all sectors exhibited significant reductions over time (all p < 0.001). Results from univariate and multivariate linear mixed model analyses revealed that age and IOP were significantly associated (p = 0.009 and 0.047, respectively) with reductions in GC ‐ IPL s in HTN patients. Conclusion Patients with HTN exhibited a significant reduction in GC ‐ IPL s compared to normal subjects. Additionally, age and IOP affected the reduction rate of GC ‐ IPL s in HTN patients. In various ophthalmic diseases, physicians should consider the longitudinal effect of HTN on GC ‐ IPL s.