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The impact of ganglion cell layer cysts in diabetic macular oedema treated with anti‐vascular endothelial growth factor
Author(s) -
Ceklic Lala,
Huf Wolfgang,
Ebneter Andreas,
Wolf Sebastian,
Zinkernagel Martin S.,
Munk Marion R.
Publication year - 2019
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.14137
Subject(s) - medicine , ophthalmology , gclc , context (archaeology) , diabetic retinopathy , epiretinal membrane , retinal , visual acuity , diabetes mellitus , endocrinology , paleontology , biochemistry , chemistry , downregulation and upregulation , biology , vitrectomy , gene
Purpose To investigate the prevalence and impact of ganglion cell layer cysts ( GCLC ) in patients with diabetic macular oedema (DME) under continuous anti‐vascular endothelial growth factor ( VEGF ) therapy. Methods The clinical findings and spectral domain optical coherence devices of baseline visits and follow‐up after 12–24 and 36 months of DME patients under continuous anti‐ VEGF therapy were retrospectively collected and analysed for the impact of GCLC cysts. Previously established prognostic parameters were also assessed. Results A total of 110 eyes of 110 DME patients (mean age 64 ± 10 years) were included. At baseline, 17% eyes had GCLC . With GCLC , the best‐corrected visual acuity (BCVA) improvement was in mean 8.4 ± 2.4 Early‐Treatment‐Diabetic‐Retinopathy‐Study (ETDRS) letters less over the course of 36 months compared to the group lacking GCLC (p = 0.0009). Eyes with GCLC showed 68 ± 23.4 μ m less central retinal thickness (CRT) decrease than eyes lacking GCLC (p < 0.0001). In the linear mixed effect models including external limiting membrane disruption, disintegration of inner retinal layer and epiretinal membrane, GCLC remained a statistical significant factor for the outcome parameter CRT , but missed statistical significance for BCVA . Conclusion Ganglion cell layer cysts ( GCLC ) seem to impact outcome in DME in patients receiving long‐term treatment. This prognostic factor warrants further evaluation in the context of already well‐established outcome parameters.