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Retinal layer thickness in preclinical Alzheimer's disease
Author(s) -
Kreeke Jacoba A.,
Nguyen HoangTon,
Haan Jurre,
Konijnenberg Elles,
Tomassen Jori,
Braber Anouk,
Kate Mara,
Collij Lyduine,
Yaqub Maqsood,
Berckel Bart,
Lammertsma Adriaan A.,
Boomsma Dorret I.,
Tan Hendra Stevie,
Verbraak Frank D.,
Visser Pieter Jelle
Publication year - 2019
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.14121
Subject(s) - retinal , ophthalmology , medicine , retina , neuroscience , psychology
Purpose There is urgent need for non‐invasive diagnostic biomarkers in the preclinical phase of Alzheimer's Disease ( AD ). Several studies suggest that retinal thickness is reduced in AD . Here, we aim to test the diagnostic value of retinal thickness in preclinical AD , as defined by cognitively normal individuals with amyloid pathology on PET . Methods One hundred and sixty five cognitively healthy monozygotic twins aged ≥ 60 were included from the Netherlands Twin Register taking part in the European Medical Information Framework for Alzheimer's Disease Preclin AD study. Participants underwent [ 18 F] flutemetamol PET that was visually rated for presence or absence of cortical amyloid beta (A β ). Binding potential ( BP ND ) was calculated as continuous measure for A β . Spectral Domain OCT was used to asses total and individual inner retinal layer thickness in the macular region ( ETDRS circles) as well as peripapillary retinal nerve fibre layer ( pRNFL ) thickness. Differences between A β + and A β − individuals and associations between BP ND and retinal thickness were analyzed. Results No differences were found in retinal layer thickness in the macula or pRNFL between A β + and A β − individuals. A positive associations between BP ND and macular total retinal thickness was observed in the inner ring (p = 0.018), but this was not statistically significant after correction for multiple testing (p = 0.144). Brain/eye parameters had moderate to high intra‐twin correlations (p < 0.001) except visual rating score of A β , which did not correlate ( r = 0.21, p = 0.068). Conclusion Variation in retinal thickness likely reflects genetic differences between individuals, but cannot discriminate between healthy and preclinical AD cases, making its use as biomarker in these early stages limited.