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Association of chronic hepatitis B virus infection with age‐related macular degeneration
Author(s) -
Wu ChiaMin,
Su FuHsiung,
Wang WenChang,
Lin ChangPing,
Kamiza Abram Bunya,
Chang ShihNi,
Yeh ChihChing
Publication year - 2019
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.14032
Subject(s) - medicine , macular degeneration , chronic hepatitis , virology , hepatitis b virus , virus , ophthalmology
Purpose To study the association between chronic hepatitis B virus ( HBV ) and age‐related macular degeneration ( AMD ). Methods Data used in this retrospective, frequency‐matched cohort study were acquired from the Longitudinal Health Insurance Database 2000, which includes medical claims and registration files for 1 000 000 enrolees in the Taiwan National Health Insurance programme. The HBV cohort contained 17 796 patients who received a diagnosis of chronic HBV infection between January 1, 2000 and December 31, 2012. The non‐ HBV cohort contained 71 184 participants who were frequency‐matched by age, sex and year of index date for comparison. Participants were followed until the end of 2013, and those who developed AMD during the study period were identified. A Cox proportional hazards regression model was used to compare the risk of AMD between cohorts. Results The incidence of any type of AMD in all participants was 3.88 per 1000 person‐years (PY; 2.27 per 1000 PY in the HBV cohort; 1.61 per 1000 PY in the non‐ HBV cohort). Compared with the non‐ HBV cohort, the adjusted hazard ratio ( HR ) for any type of AMD in the HBV cohort was 1.41 [95% confidence interval ( CI ) 1.23–1.63; p < 0.001]. This significant positive association was stronger among patients who exhibited disease progression from nonexudative to exudative AMD (adjusted HR = 1.74, 95% CI : 1.01–2.99). Conclusion Our results suggest that patients with chronic HBV infection in Taiwan have a significantly elevated risk of developing any type of AMD and that HBV infection may accelerate the progression of AMD .