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Functional MRI reveals effects of high intraocular pressure on central nervous system in high‐tension glaucoma patients
Author(s) -
Wang Yi,
Lu Weizhao,
Yan Tingqin,
Zhou Jian,
Xie Yuanzhong,
Yuan Jiumin,
Liu Guangling,
Teng Yufang,
Han Wenhui,
Chen Di,
Qiu Jianfeng
Publication year - 2019
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.14027
Subject(s) - medicine , ophthalmology , intraocular pressure , glaucoma , cerebellar hemisphere , functional magnetic resonance imaging , magnetic resonance imaging , resting state fmri , superior frontal gyrus , cerebellum , radiology
Purpose To evaluate the effects of high intraocular pressure ( IOP ) on central nervous system in patients with high‐tension glaucoma ( HTG ) by using resting‐state functional magnetic resonance imaging (rs‐ fMRI ). Methods Thirty‐six patients with HTG and twenty age‐ and gender‐matched healthy controls ( HC s) were recruited and underwent IOP measurement and rs‐ fMRI scan. The whole brain regional homogeneity (ReHo) value was calculated among the enrolled subjects. Two‐sample t tests with permutation test and threshold‐free cluster enhancement was performed between HTG group and HC s. Correlation analyses between IOP and ReHo values were conducted. Results Compared with HC s, HTG group showed increased ReHo values in the left lobule 8 of cerebellar hemisphere, left lobule 4 and 5 of cerebellar hemisphere and left fusiform gyrus ( FG ) (p < 0.05). HTG group showed decreased ReHo value in the left middle frontal gyrus ( MFG ) (p < 0.05). Intraocular pressure of the left eye in HTG group experienced a significant positive correlation with ReHo value of the left FG ( r = 0.370, p = 0.026), IOP of the right eye in HTG group showed a significant negative correlation with ReHo value in the left MFG ( r = −0.421, p = 0.011). Conclusion Resting‐state fMRI ReHo analyses associated elevated IOP with abnormal regional activity in several brain regions related to higher visual function and visual memory consolidation. High‐tension glaucoma patients also showed diminished integration of visual information and cerebellar function. These results may provide imaging support for pathophysiological research of HTG and may reveal new targets for the accurate treatment of HTG .