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Macular perfusion velocities in the ocular ischaemic syndrome
Author(s) -
Klefter Oliver Niels,
Kofoed Peter Kristian,
Munch Inger Christine,
Larsen Michael
Publication year - 2019
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.13950
Subject(s) - medicine , perfusion , ophthalmology , blood flow , fundus (uterus) , ophthalmic artery , retinal , fundus photography , visual acuity , fluorescein angiography , cardiology
Purpose To assess retinal perfusion in eyes with unilateral ocular ischaemic syndrome ( OIS ) and to compare with control subjects. Methods Retrospective case series. Linear blood flow velocities in macular vessels were estimated using motion‐contrast fundus photography in eight patients with unilateral OIS (eight OIS eyes, seven fellow eyes) and 12 control subjects. The diagnosis of OIS was supported by carotid artery Doppler ultrasonography and pneumoplethysmographic measurement of ocular systolic perfusion pressure. Results Macular arterial blood flow velocity (median, range) was 1.8 (1.4–2.7) mm/s in OIS eyes, 4.0 (2.9–5.3) mm/s in fellow eyes (p = 0.016) and 3.8 (2.3–5.1) mm/s in control eyes (p = 0.0004 and p = 0.67 versus OIS and fellow eyes, respectively). Macular venous blood flow velocity was 1.5 (1.0–2.1) mm/s in OIS eyes, 2.6 (2.0–2.9) mm/s in fellow eyes (p = 0.016) and 2.7 (1.8–3.5) mm/s in control eyes (p = 0.0007 and p = 0.64). Arterial velocities were below or equal to the lowest value observed in control subjects (≤2.3 mm/s) in seven of eight eyes with OIS . Visual acuity 0.7 or worse was found in two OIS eyes with arterial velocities below 1.7 mm/s and venous velocities below 1.3 mm/s and together with neovascular glaucoma or polycythemia vera (one eye each). Conclusion Motion‐contrast imaging revealed markedly reduced macular perfusion velocities in OIS eyes compared with unaffected fellow eyes and healthy control eyes. The method appears to provide a clinically meaningful quantitative measure of macular hypoperfusion.