Premium
Quality of life: fractionated stereotactic radiotherapy versus enucleation treatment in uveal melanoma patients
Author(s) -
Beek Jackelien G.M.,
Buitendijk Gabrielle H.S.,
Timman Reinier,
Muller Karin,
Luyten Gregorius P.M.,
Paridaens Dion,
Naus Nicole C.,
Kiliç Emine
Publication year - 2018
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.13823
Subject(s) - medicine , enucleation , quality of life (healthcare) , stereotactic radiotherapy , anxiety , state trait anxiety inventory , radiation therapy , distress , melanoma , surgery , radiosurgery , clinical psychology , nursing , cancer research , psychiatry
Purpose To report the quality of life and visual functioning in uveal melanoma patients treated with enucleation or fractionated stereotactic radiation therapy ( fSRT ). Methods Uveal melanoma (UM) patients treated with fSRT ( n = 65) or enucleation ( n = 48) participated in this prospective study. Questionnaires to measure anxiety (State‐Trait Anxiety Inventory), subjective distress (Impact of Event Scale) and quality of life ( EORTC ‐ QLQ ‐C30 and National Eye Institute Visual Function Questionnaire ( VFQ ‐25)) were obtained before treatment and 2, 6, 12, 24, 36 and 48 months after treatment. Results Less peripheral vision was observed until 3 years (p = 0.026) posttreatment in enucleated patients compared to irradiated patients. From 2 months until 3 years posttreatment irradiated patients increase in role functioning‐score (p = 0.005), while enucleated patients decrease in score (p = 0.012). Regardless of their treatment, for all patients we measured a reduction in physical functioning (p = 0.035), insomnia (p < 0.001) and in state anxiety from pretreatment until 2 years posttreatment (p < 0.001). An increase in pain overall (p = 0.023) and in emotional functioning is observed 1 year posttreatment (p < 0.001). At baseline, patients with metastases (independent of their treatment) have more subjective distress (p = 0.037) than patients without metastases. The mean ‘global health score’ overall, without effect of time, was 76.4 ( SD : 13.6). Conclusion Enucleated patients had more difficulty working or performing household tasks 2 months posttreatment compared to irradiated patients. Enucleated patients had diminished peripheral vision until 3 years compared to irradiated patients. Overall quality of life is not significantly different between both treatment groups.