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Increased risk of open‐angle glaucoma among patients with diabetes mellitus: a 10‐year follow‐up nationwide cohort study
Author(s) -
Rim Tyler Hyungtaek,
Lee Sang Yeop,
Bae Hyoung Won,
Seong Gong Je,
Kim Sung Soo,
Kim Chan Yun
Publication year - 2018
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.13805
Subject(s) - medicine , diabetes mellitus , hazard ratio , cohort , glaucoma , propensity score matching , open angle glaucoma , retrospective cohort study , incidence (geometry) , cohort study , confidence interval , pediatrics , ophthalmology , endocrinology , physics , optics
Purpose To evaluate the risk of open‐angle glaucoma among patients with diabetes. Methods This retrospective propensity score‐matched cohort study included patients with diabetes and a matched comparison group from the Korean National Health Insurance Service National Health Screening Cohort, which includes approximately 500 000 adults aged ≥40 years. Nondiabetes group was matched to diabetes group in a 1:1 ratio using a propensity score based on age, sex, comorbidities, antihypertensive medication use and medical care visits. Each group was followed from January 1, 2004 to either the date of developing open‐angle glaucoma or the date of last follow‐up in 2013. Results Incidence of open‐angle glaucoma was 20.0/10 000 person‐years in diabetes group ( n = 58 358) and 17.0/10 000 person‐years in nondiabetes group ( n = 58 358). Age‐ and sex‐ adjusted hazard ratio ( HR ) was 1.19 (95% confidence interval [ CI ], 1.09–1.30). In the subgroup analyses, diabetes was associated with an increased risk of open‐angle glaucoma in both younger and older age groups ( HR = 1.20 for those aged 40–59 years and HR = 1.18 for those aged 60–79 years) and in both sexes (men, HR = 1.13; women, HR = 1.27). Conclusion Patients diagnosed with diabetes were more likely to develop open‐angle glaucoma compared with patients without diabetes.