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Cosmetic results of enucleation and/or external beam radiation therapy in 195 retinoblastoma survivors
Author(s) -
Mourits Daphne L.,
Hartong Dyonne T.,
LissenbergWitte Birgit I.,
Bosscha Machteld I.,
Tan H. Stevie,
Moll Annette C.
Publication year - 2018
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.13729
Subject(s) - medicine , implant , enucleation , ptosis , eyelid , eye enucleation , retinoblastoma , surgery , enophthalmos , prosthesis , diplopia , biochemistry , chemistry , gene
Purpose To report the cosmetic outcome and late effects of enucleation and/or irradiation for retinoblastoma and to evaluate the role of orbital implants. Methods Patients (age >4 years) enucleated and/or irradiated for retinoblastoma, visiting the hospital for routine follow‐up (April 2013 to May 2015), were included in our cross‐sectional study. Data were obtained via clinical records, questionnaires, physical measurements and standardized photographs. Two independent observers scored the cosmetic features: upper eyelid position, lower eyelid position, volume deficiency, and prosthesis motility and overall cosmetic appearance. Results A total of 195 patients participated. Ptosis was seen in 45 (28.3%) patients, lower lid sagging in 45 (28.3%). Both complications were associated with the orbital implant; ptosis being more common with increasing implant size (5.6% without implant, 16.7% with small implant, 37.1% with medium implant and 76.9% with large implant) and lower lid sagging being more common in patients without implant (20% with implant versus 37.5% without). Volume loss of the superior sulcus was seen in 107 sockets (66.9%), most frequent in additionally irradiated patients ( χ 2 (2) = 42.7, p < 0.001) and in patients without implant ( χ 2 (2) = 11.92, p = 0.003). Prosthesis motility was better in patients with orbital implant, regardless of the size. Conclusion Minor late and potentially treatable effects were seen in patients with implant. Larger sized implants were associated with a higher incidence of ptosis; implant size did not affect subjective outcome with respect to volume or prosthetic motility. Treatment with EBRT had a less favourable outcome.