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Noninvasive evaluation of cerebrospinal fluid pressure in ocular hypertension: a preliminary study
Author(s) -
Xie Xiaobin,
Chen Weiwei,
Li Zhen,
Thomas Ravi,
Li Yong,
Xian Junfang,
Yang Diya,
Wang Huaizhou,
Zhang Shoukang,
Kang Zefeng,
Wang Ningli
Publication year - 2018
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.13724
Subject(s) - cerebrospinal fluid pressure , medicine , subarachnoid space , cerebrospinal fluid , glaucoma , magnetic resonance imaging , nuclear medicine , ocular hypertension , cerebral spinal fluid , anesthesia , ophthalmology , radiology
Purpose To compare the orbital cerebral spinal fluid pressure ( CSFP ) and trans‐lamina cribrosa pressure difference ( TLCPD ) determined noninvasively in ocular hypertensive ( OH ) subjects and controls. Methods Cross‐sectional observational study. Magnetic resonance imaging was used to measure orbital subarachnoid space width ( OSASW ). The CSFP (mm Hg) was estimated from a published formula as 17.54 × MRI derived OSASW at 15 mm behind the globe + 0.47 × body mass index + 0.13 × mean arterial blood pressure −21.52. Estimated TLCPD was calculated as IOP ‐ CSFP . Results The orbital subarachnoid space width was significantly wider (p = 0.01) in the OH group than in the control group at all three measurement locations. The MRI derived CSFP value in OH (14.9 ± 2.9 mm Hg) was significantly higher than in the normal group (12.0 ± 2.8 mm Hg; p < 0.01). The estimated TLCPD value in OH (9.0 ± 4.2 mm Hg) was significantly higher than in controls (3.6 ± 3.0 mm Hg; p < 0.01). Conclusion The wider OSASW and higher estimated CSFP in OH subjects suggest a higher orbital CSFP . Despite a higher orbital CSFP that could be protective, the higher TLCPD in OH may play a significant role in the risk of developing glaucoma.