Premium
Optical coherence tomography angiography in patients with retinitis pigmentosa who have normal visual acuity
Author(s) -
Takagi Seiji,
Hirami Yasuhiko,
Takahashi Masayo,
Fujihara Masashi,
Mandai Michiko,
Miyakoshi Chisato,
Tomita Goji,
Kurimoto Yasuo
Publication year - 2018
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.13680
Subject(s) - external limiting membrane , ophthalmology , foveal avascular zone , medicine , visual acuity , optical coherence tomography angiography , foveal , fundus (uterus) , optical coherence tomography , retinal , retinitis pigmentosa , fovea centralis , fluorescein angiography , retinal pigment epithelium
Purpose To investigate flow area changes measured using optical coherence tomography angiography ( OCTA ; RTV ue XR Avanti ® ) in patients with retinitis pigmentosa ( RP ) with preserved visual acuity (VA). Methods This was an age‐ and refraction‐matched case–control study. Consecutive patients with a best‐corrected visual acuity (BCVA) of ≥20/20 and normal subjects were recruited. Fifty eyes (32 patients) and 22 eyes (12 controls) were included. The flow area and foveal avascular zone ( FAZ ) were measured in both superficial and deep layers within a 3 × 3 mm central area of the fovea. Association between OCTA parameters and the length of the inner segment ellipsoid ( IS e) and external limiting membrane ( ELM ), the area without abnormal fluorescence in fundus autofluorescence (normal FAF area ratio) and the area of I‐2e of the Goldmann perimeter were analysed using mixed‐effects regression analysis. Results Foveal avascular zones were significantly smaller in patients with RP than in controls in superficial (p = 0.004) but not in deep layers (p = 0.25). The flow area in superficial (p = 0.007) and deep layers (p = 0.004) was significantly smaller in patients with RP than in controls. In patients with RP , flow areas in the superficial layers, but not in the deep layers, were significantly associated with the lengths of IS e (p = 0.001) and ELM (p = 0.002) and the I‐2e area (p = 0.036), but not with the normal FAF area ratio (p = 0.399). Conclusion Optical coherence tomography angiography (OCTA)‐measured flow area in superficial layers gradually reduced with RP progression and may be a useful parameter of RP pathogenesis.