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Multispectral image analysis in Vogt–Koyanagi–Harada disease
Author(s) -
Huang Guo,
Peng Junchao,
Ye Zi,
Kijlstra Aize,
Zhang Donglei,
Yang Peizeng
Publication year - 2018
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.13606
Subject(s) - vogt–koyanagi–harada disease , medicine , fundus (uterus) , depigmentation , ophthalmology , fundus photography , retinal pigment epithelium , retinal , fluorescein angiography , dermatology , uveitis
Purpose To investigate fundus abnormalities in Vogt–Koyanagi–Harada (VKH) disease by a noninvasive tool, multispectral imaging ( MSI ). Methods A total of 77 patients with VKH and 163 healthy controls were enrolled between January and April 2015. The MSI findings were evaluated in combination with fundus fluorescein angiography ( FFA ), optical coherent tomography ( OCT ) and fundus photography ( FP ). Additionally, we compared extent of exposure of choroidal blood vessels between patients with VKH and healthy controls to evaluate retinal transmission function. Results A number of features could be recognized by MSI which included (i) general depigmentation, (ii) clumping of pigment and (iii) macular depigmentation and/or hyperpigmentation. The percentages of these three abnormalities discovered by MSI in 52 inactive VKH patients with a duration of more than 2 months in VKH were 67.3%, 75% and 84.6% respectively, which were all significantly higher than those detected by FFA , OCT or FP (p = 0.0398, p < 0.0001). Our study showed that MSI detected a higher percentages of these four abnormalities in patients with sunset glow fundus than in patients without this phenomenon (p = 0.0492, p < 0.0001). Additionally, at the same wavelength (590 nm), exposure of choroidal blood vessels in inactive patients was stronger than in healthy controls and active patients (p < 0.01, p < 0.001). Conclusion Our results show that MSI is a sensitive noninvasive method to investigate the retinal pigment epithelium ( RPE ) in VKH disease. It is more likely to detect RPE abnormalities with MSI than when using FFA , OCT or FP . Retinal transmission function in inactive patients is stronger than that observed in active patients or healthy controls.