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Vascular and metabolic comorbidities in open‐angle glaucoma with low‐ and high‐teen intraocular pressure: a cross‐sectional study from South Korea
Author(s) -
Lee Si Hyung,
Kim Gyu Ah,
Lee Wonseok,
Bae Hyoung Won,
Seong Gong Je,
Kim Chan Yun
Publication year - 2017
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.13487
Subject(s) - medicine , glaucoma , intraocular pressure , stroke (engine) , confounding , logistic regression , hyperlipidemia , cross sectional study , metabolic syndrome , open angle glaucoma , blood pressure , cardiology , national health and nutrition examination survey , ophthalmology , diabetes mellitus , obesity , population , endocrinology , mechanical engineering , environmental health , pathology , engineering
Purpose To assess the associations between vascular and metabolic comorbidities and the prevalence of open‐angle glaucoma ( OAG ) with low‐teen and high‐teen intraocular pressure ( IOP ) in Korea. Methods Cross‐sectional data from the Korean National Health and Nutrition Examination Survey from 2008 to 2012 were analysed. Participants diagnosed with OAG with normal IOP were further classified into low‐teen IOP ( IOP ≤ 15 mmHg) and high‐teen IOP (15 mmHg < IOP ≤ 21 mmHg) groups. Using multiple logistic regression analyses, the associations between vascular and metabolic comorbidities and the prevalence of glaucoma were investigated for the low‐ and high‐teen IOP groups. Results The prevalences of hypertension, hyperlipidemia, ischaemic heart disease, stroke and metabolic syndrome were significantly higher among subjects with low‐teen OAG compared with normal subjects, while only the prevalences of hypertension and stroke were higher among subjects with high‐teen OAG compared with normal subjects. In multivariate logistic regression models adjusted for confounding factors, low‐teen OAG was significantly associated with hypertension ( OR , 1.68; 95% CI , 1.30–2.18), hyperlipidemia ( OR , 1.49; 95% CI , 1.07–2.08), ischaemic heart disease ( OR , 1.83; 95% CI , 1.07–3.11), stroke ( OR , 1.91; 95% CI , 1.12–3.25) and metabolic syndrome ( OR , 1.46; 95% CI , 1.12–1.90). High‐teen OAG was only associated with stroke ( OR , 2.58; 95% CI , 1.20–5.53). Conclusion Various vascular and metabolic comorbidities were significantly associated with low‐teen OAG , but not with high‐teen OAG . These data support the hypothesis that vascular factors play a more significant role in the pathogenesis of OAG with low‐teen baseline IOP .