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Bilateral diffuse uveal melanocytic proliferation: Case report and literature review
Author(s) -
Klemp Kristian,
Kiilgaard Jens Folke,
Heegaard Steffen,
Nørgaard Tove,
Andersen Mette Klarskov,
Prause Jan Ulrik
Publication year - 2017
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.13481
Subject(s) - medicine , malignancy , dermatology , ophthalmology , iris (biosensor) , retinal detachment , ciliary body , pathology , retinal , computer security , computer science , biometrics
Abstract Bilateral diffuse uveal melanocytic proliferation ( BDUMP ) is a rare paraneoplastic intraocular disease that causes progressive visual loss in patients driven by an IgG factor associated with an underlying malignancy. Characteristic ocular findings include exudative retinal detachment, rapid cataract formation and uveal melanocytic tumours. The awareness and documentation of BDUMP has increased during the past decade, and the increasing amount of data collected demonstrates the effect of treatment with plasmapheresis and the value of diagnostic tools in BDUMP such as genetic and immunologic investigations. The literature of BDUMP has not been reviewed since 2003, and there is a growing need for an updated review on diagnosis and management of BDUMP . We review the literature and report a case of BDUMP with a white ciliary body tumour, iris rubeosis, increased iris pigmentation and cataract.