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Neovascular age‐related macular degeneration is not associated with coronary heart disease in a Chinese Population: a population‐based study
Author(s) -
Hu ChaoChien,
Lin HerngChing,
Sheu JauJiuan,
Kao LiTing
Publication year - 2017
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.13204
Subject(s) - macular degeneration , medicine , coronary heart disease , chinese population , disease , ophthalmology , cardiology , population , environmental health , biochemistry , chemistry , gene , genotype
Purpose This case–control study aimed to explore the association between prior coronary heart disease ( CHD ) and neovascular age‐related macular degeneration (AMD) using a population‐based data set in Taiwan. Methods We analysed data sourced from the Taiwan Longitudinal Health Insurance Database 2005. The study consisted of 1970 patients with neovascular AMD as cases and 5910 age‐ and sex‐matched controls. We performed a conditional logistic regression to examine the odds ratio ( OR ) and its corresponding 95% confidence interval ( CI ) for previously diagnosed CHD between cases and controls. Results Of the 7880 sampled patients, 24.5% had a prior history of CHD ; CHD was found in 25.7% of cases and in 22.7% of controls (p = 0.008). The conditional logistic regression analysis indicated that the OR for prior CHD for cases was 1.17 [95% confidence interval ( CI ): 1.04–1.32] compared to the controls. However, after adjusting for patient's monthly income, geographic location, urbanization level, age, hyperlipidaemia, diabetes and hypertension, we failed to observe an association between prior CHD and AMD ( OR = 1.03, 95% CI = 0.91–1.17). Additionally, the medical comorbidities of hyperlipidaemia (adjusted OR = 1.29, 95% CI = 1.15–1.45), hypertension (adjusted OR = 1.20, 95% CI = 1.05–1.37) and diabetes (adjusted OR = 1.47, 95% CI = 1.32–1.65) were significantly associated with AMD . Conclusions This study presented no significant difference in the odds of prior CHD between patients with AMD and those without AMD after adjusting for comorbidities and sociodemographic characteristics in a Chinese population.